THE DRUG-FASTNESS OF SPIROCHETES TO ARSENIC, MERCURIAL, AND IODIDE COMPOUNDS IN VITRO
نویسندگان
چکیده
منابع مشابه
The Drug-fastness of Spirochetes to Arsenic, Mercurial, and Iodide Compounds in Vitro
In the foregoing experiments we attempted to determine whether or not, by subjecting several varieties of spirochetes to increasing doses of certain chemotherapeutic agents, a gradual increase of resistance to the latter could be shown. For this purpose, pure cultures of Treponema pallidum, Treponema microdentium, and Spirochoeta refringens were used against the action of salvarsan, neosalvarsa...
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The majority of the 76 new compounds possessed spirocheticidal powers ranging between 1: 1,000 (30) to 1:2,500 (14), while only 2 attained the power of 1:5,000, 1 of 1: 25,000, and 2 of 1: 50,000. On the other hand, 8 killed the spirochetes in a dilution of 1: 750, 10 in 1:500, 7 in 1:250. 1 in 1: 100, and 1 in 1:50. It may be mentioned that the 2 (M1, M4) of 1:50,000 and 1 (M7) of 1:25,000 bel...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1917
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.25.3.349